IL5 and Increased total eosinophil count: TPE: Humans:  • Acute eosinophil infiltration and eosinophilic inflammation  • Eosinophil-associated proteins in BAL and serum  • DEC treatment: reduced MF counts and eosinophil inflammation Animal model:  • Neutralization of α4 and β7 integrins, IL-12 administration, IL-5 KO mice + dblGATA mice: reduced lung damage and reduced eosinophilia