CTLA4 and neoplasm: Overall, our findings show that high expression of most immunoreceptors, apart from PD-1, PD-L1/L2 and CTLA-4 that have been already tested in the clinical setting, associates with the TIL load and patient survival, but not with the TMB, in contrast to other, less hypermutated and/or non-inflamed tumor types (24, 53).