TTN and cutaneous melanoma: In total, 25 genes were recurrently mutated in skin melanoma, including TTN (156 missense out of a total of 228 mutations), BRAF (141 missense out of a total of 146 mutations), XIRP2 (91 missense out of a total of 118 mutations), THSD7B (76 missense out of a total of 105 mutations), USH2A (80 missense out of a total of 104 mutations), NRAS (85 missense out of a total of 88 mutations), RLN (50 missense out of a total of 88 mutations) and TPTE (45 missense out of a total of 75 mutations), among others, having a lower mutation frequency (Figure 3).