CTLA4 and cutaneous melanoma: Paradoxially, however, the expression of several well-known inhibitory receptors, including CTLA-4, PDCD1 (PD-1), TIGIT, IDO1, LAG3, ADORA2A and VTCN1, was similar between TMBhigh and TMBlow tumors, corroborating that in general, the expression of immune checkpoints and TMB are independent biomarkers in skin melanoma.