found that forkhead box P transcription factor 1 (Foxp1) is a negative regulator of NLRP3 inflammasome activation in ECs, and they also revealed found that Foxp1 is significantly downregulated in atherosclerosis-susceptible endothelium and Foxp1 knockout in ApoE-/- mice exacerbates atherosclerosis. This evidence concerns the gene APOE and atherosclerosis.