found that m7G tRNA modification and its catalase metttl1 were expressed elevated in HCC, and METTL1-mediated m7G tRNA modification could promote mRNA translation, which was shown to accelerate the development and progression of hepatocellular carcinoma and correlated with poor prognosis of hepatocellular carcinoma by in vitro and in vivo experiments (24). Here, METTL1 is linked to hepatocellular carcinoma.