EGFR and intrahepatic cholangiocarcinoma: found in their recent studies that METTL1 and WDR4 were upregulated in patients with intrahepatic cholangiocarcinoma(ICC) and that METTL1-mediated m7G tRNA modification selectively regulated oncogenic genes including EGFR pathway and cell cycle genes in ICC through a codon frequency-dependent mechanism mRNA translation.