The tumor suppressive genes of the NRGPI (suppressed in NRGPI-High subgroup), the E2F2 and EFNA3, were regulated by a group of 4 microRNAs (E2F2: hsa-miR-490-3p and hsa-miR-145-5p; EFNA3: hsa-let-7c-5p and hsa-miR-133a-3p) (Figures 8H–K). The gene discussed is E2F2; the disease is neoplasm.