Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and mixed lineage kinase domain like pseudokinase (MLKL), which constitutes the core components of necroptosis, are downregulated in various types of cancers including colorectal cancer, pancreatic adenocarcinoma, cervical squamous cell carcinoma, and melanoma (6, 7, 9–13). The gene discussed is MLKL; the disease is colorectal cancer.