IL37 and rheumatic disorder: For example, IL-37, a member of the IL-1 family which is stimulated by SARS-CoV-2, has been shown to suppress IL-1β, IL-6, TNFα and CCL2 in rheumatic diseases by acting on mTOR and enhancing the AMPK activity, to maintain mitochondrial membrane potential and limit the toxic effects of ROS (51).