For example, IL-37, a member of the IL-1 family which is stimulated by SARS-CoV-2, has been shown to suppress IL-1β, IL-6, TNFα and CCL2 in rheumatic diseases by acting on mTOR and enhancing the AMPK activity, to maintain mitochondrial membrane potential and limit the toxic effects of ROS (51). The gene discussed is CCL2; the disease is rheumatic disorder.