ANO1, also called TMEM16A, ORAOV2, DOG1, TAOS2, and FLJ10261, is a calcium-activated chloride channel, and its overexpression can promote the attachment, spread, detachment, and invasion of HNSCC cells and can be used as a marker for distant metastasis of HNSCC (47). This evidence concerns the gene ANO1 and head and neck squamous cell carcinoma.