Therefore, we conclude that antibiotic treatment reduces asthma possibly due to dysfunction of ADRB2.In conclusion, we showed that antibiotic treatment for 2 weeks in post-weaning mice relieved OVA-induced allergic asthma, accompanied with reduced frequency of iNKT cells and increased expressions of Adrb2. Additionally, ADRB2+ DCs were increased in asthmatic lungs and might be involved in promoting the development of allergic asthma. Here, ADRB2 is linked to allergic asthma.