The main classes of drugs used for the evaluation of sepsis treatment are immunostimulatory drugs (immune targets CSF2RA/B, CSF3R) (52), immunostimulatory cytokines (immune target is IFNGR1/2) (53), and immunosuppressants (PDL1 and CTLA4) (54). The gene discussed is IFNGR1; the disease is Sepsis.