In this study, a prognostic model including three necroptosis-related genes (EZH2, Enhancer of zeste homolog 2; LEF1, Lymphocyte enhancer factor-1, and CASP1, Caspase-1) was constructed based on The Cancer Genome Atlas (TCGA) training set and validated in two Chinese Glioma Genome Atlas (CGGA) validation sets. The gene discussed is LEF1; the disease is glioma.