Analysis of candidate genes in children with SLE and their parents has confirmed the involvement of SLE-associated genes, including SELP (P-selectin gene) and IRAK1 (interleukin-1 receptor-associated kinase 1 gene), that are overexpressed in CD4+ Treg from patients with SLE (33, 34). Here, CD4 is linked to systemic lupus erythematosus.