In particular, autoreactive CD4+ T cells are considered to play a central role in the initiation and perpetuation of the pathologic immune responses in several ways: Follicular T helper (Tfh) cells, which represent a subset of CD4+ T helper cells and which have the unique capability to migrate to the outer edge of the B cell follicles in the lymphatic organs in order to initiate germinal-center reactions (4), are essential for the activation and differentiation of autoreactive B cells in SLE (5, 6). The gene discussed is CD4; the disease is systemic lupus erythematosus.