PDCD1 and Ito hypomelanosis: Multiplex cytokine profiling in lung homogenates from anti-PD-1-treated mice with IPA revealed significant induction of key pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and neutrophil-attracting chemokines (e.g., CXCL2) compared with isotype-treated controls (47).