When the expression areas of pericytes in CRC tissues were compared between patients who received rHE before surgery and those who did not receive rHE, it was found that the expression levels of α-SMA markers in pericytes in the rHE group were significantly higher than those in the non-rHE group (Figures 6A, B), which indicated that rHE could be used to normalize the tumor vasculature. Here, ACTA1 is linked to colorectal carcinoma.