Moreover, the expression of F4/80, CD11c, and MHC-II on MDSCs indicates that the differentiation of MDSCs into potent antigen-presenting cells has a strong capacity to promote Th1 differentiation, as well as enhance the cytotoxic function of CD8+ T cells, which leads to a decrease in tumor burden in a Lewis lung carcinoma (LLC) mouse lung cancer model (31). This evidence concerns the gene CD8A and lung cancer.