For example, some proteases in thyroid cancer are elevated in tumors (67):transmembrane protease serine 4 promotes thyroid cancer proliferation through cAMP response element-binding protein (CREB) phosphorylation (68), and the HIV protease inhibitor nefinavir induces apoptosis of thyroid medulla cancer cells by downregulating RET signalling (69). This evidence concerns the gene CREB1 and thyroid gland carcinoma.