IGFBP2 and neoplasm: As shown in the heatmap and violin diagram, there were significant differences in 16 genes between normal and tumor tissues, including significantly upregulated expression of HNRNPC, IGFBP2, ELF3, and RBM15B and downregulated expression of ZC3H13, FTO, KIAA1429, WTAP, YTHDC1, YTHDC2, ALKBH5, RBM15, METTL3, METTL14, YTHDC1, and CBLL1 in the TCGA-THCA cohort (Figures 2A, B).