CD40LG and inflammatory bowel disease: A prospective cohort study in Canada conducted serological testing for VCA-IgM, VCA-IgG, and EBNA-IgG in 263 patients, and the results showed that the prevalence of EBV seronegativity in the IBD population aged 18-25 years was 29%, which was similar to that in the general population; however, EBV seropositivity reached 100% in those older than 25 years, and seropositivity was associated with thiopurine use (84).