More interestingly, lymphopenia is also well explained by the fact that SARS-CoV-2 may trigger the production of proinflammatory cytokines, including IL-1β, IL-8, IL-6, CXCL8/IL-8, TNF, and CXCL10/IP-10 in infected macrophages and dendritic cells, which directly decimate lymphoid organs, including spleen, lymph nodes, bone marrow, and thymus, and therefore blocking T-cell (including CD8+ T-cell) activation (61, 64, 65, 102–104). Here, CD8A is linked to lymphopenia.