This is in contrast to ma CLCA1, for which its proposed role as modifier in cystic fibrosis (Hauber et al., 2003; Ritzka et al., 2004; Young et al., 2007) has stimulated the generation of several knockout models in mice (Erickson et al., 2018; Erickson et al., 2015; Long et al., 2006; Mundhenk et al., 2012; Nyström et al., 2018; Patel et al., 2006; Robichaud et al., 2005). The gene discussed is CLCA1; the disease is cystic fibrosis.