SULT2A1 and major depressive disorder: Similarly, lower DHEAS to cortisol ratio has been reported in humans with dementia (Ferrari & Magri, 2008), depression (Mocking et al., 2015), and in aged rhesus monkeys (Macaca mulatta) exhibiting depression-like behaviors compared to age-matched controls (Goncharova, Marenin & Oganyan, 2010).