VIRMA and cardiovascular disorder: Meanwhile, KIAA1429 participates in the occurrence and development of non-neoplastic diseases such as reproductive system disease (Hu et al., 2020) , cardiovascular system disease (Wang et al., 2021), respiratory system disease (Fei et al., 2022; Dai et al., 2021), and orthopedic diseases (Zhu et al., 2021) (Fig. 1).