Regarding this, the deficiency of the ClpP protease in mice is metabolically beneficial and has been associated with the lean body phenotype, increased energy expenditure, improved glucose homeostasis, insulin resistance, protection from high fat diet-induced obesity, and protection from hepatic steatosis (Becker et al., 2018; Bhaskaran et al., 2018). The gene discussed is CLPP; the disease is obesity due to melanocortin 4 receptor deficiency.