Cytokine-cytokine receptor interaction, cell cycle, complement and coagulation cascades, Staphylococcus aureus infection, prion diseases, oocyte meiosis, malaria, pertussis, neuroactive ligand-receptor interaction, and the renin-angiotensin system were the top ten results of KEGG functional enrichment analysis (Figure 2D). The gene discussed is REN; the disease is pertussis.