These genes included laminin subunit beta 1(LAMB1), ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), alpha thalassemia/mental retardation syndrome X-linked (ATRX), and methyl-CpG binding domain protein 1 (MBD1) (Supplementary Table 1a). The gene discussed is ATRX; the disease is Alpha-thalassemia.