IFNG and colitis: Two recombinant T. spiralis serpins, rTsKaSPI and rTsAdSPI, ameliorated the severity of TNBS-induced colitis, which was related to the decreased expression of IFN-γ, a proinflammatory cytokine that interacts with multiple signaling pathways of the innate and adaptive immune responses (Xu et al., 2018).