Rodrigues et al., 2021 found NLRP3 and apoptosis-associated speck-like protein containing caspase activation and recruitment domain (ASC) puncta in monocytes and lung tissues of moderate and severe COVID-19 patients, which proved that NLRP3 inflammatory bodies are activated after SARS-CoV-2 infection and are present in COVID-19 patients (Rodrigues et al., 2021). This evidence concerns the gene NLRP3 and COVID-19.