In LC patients, our correlation analysis demonstrated that Staphylococcus, Lautropia and Gemella were positively correlated with TNF-α; Leptotrichia was positively correlated with MIP-1α; Parvimonas was positively correlated with MIP-1β and RANTES; whereas Prevotella was negatively correlated with IL-5 and IL-7. This evidence concerns the gene CCL4 and laryngotracheoesophageal cleft.