Thus, in patients with hyperparathyroidism, who have in adenomatous altered tissue increase in the expression of type 1 angiotensin II receptors, the concomitant hyperaldosteronism can aggravate arterial-stiffness, endothelial dysfunction, blood pressure elevation, cardiac hypertrophy and cardiovascular disease [11, 12]. This evidence concerns the gene AGTR1 and hyperparathyroidism.