Thus, the 3 hub effective components (luteolin, kaempferol, and quercetin) and 8 targets (VEGF, CASP3, JUN, TP53, AKT1, IL6, TNF, and MMP9) might play essential roles in the treatment of pneumonia by YHPGKL. The gene discussed is AKT1; the disease is susceptibility to pneumonia measurement.