Aggregates of α-synuclein in neuron are also n vital character of PD (Sadatomi et al., 2013), and in a previous study of our team, the predictive value of plasma oligomeric α-syn had been checked (Zhao et al., 2022); when plasma PGAM5 combines with oligomeric α-syn, the diagnostic utility of plasma PGAM5 would also be enhanced. The gene discussed is PGAM5; the disease is Parkinson disease.