In this study, the independent association between the genotypes (TNF-α rs1800629, TNF-α rs361525, IFNG rs2069705, IL1-a rs1800587, and IL6 rs1800796) was confirmed in the multilocus epistasis analysis, which may indicate that, at least in this population, the combination of these polymorphisms could constitute a genetic risk marker for the development of dementia. The gene discussed is TNF; the disease is dementia.