One of the long-term complications of diabetes in the nervous system is called diabetic encephalopathy (DACI), which is characterized by cognitive impairment and neuropathological changes, mainly manifested by altered synaptic plasticity (Wang B. N. et al., 2021), extracellular plaques of aggregated amyloid beta (Aβ), and neurofibrillary tangles composed of hyperphosphorylated tau protein (Pang et al., 2022). The gene discussed is MAPT; the disease is diabetic encephalopathy.