IL6 and neurodegenerative disease: Choi et al. (2019) found that the central nervous system inflammation is closely associated with pathological neurodegenerative diseases. Some studies have shown that proinflammatory cytokines (IL-1β, IL-6, and TNF-α) can interfere with insulin signal transduction and participate in insulin resistance and DACI (Degirmenci et al., 2019).