Activation of NLRP3-mediated inflammatory responses impairs microglial autophagy and exacerbates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced pro-inflammatory responses to PD-like symptoms (Cheng et al., 2020; Qin et al., 2021). The gene discussed is NLRP3; the disease is Parkinson disease.