Cannabidiol (CBD) can inhibit IL-6 release and improve microglial activation, and there is a correlation between CBD-induced signal transducer and activator of transcription 3 (STAT3) and NF-κB phosphorylation, indicating that CBD may have therapeutic potential for treating neurological diseases involving neuroinflammation (Wu et al., 2021a; Table 1). This evidence concerns the gene STAT3 and nervous system disorder.