For example, CREB3, STAT1, and STAT3 are important regulators of glucose and lipid metabolism in models of high-fat diet and obesity (Bone et al., 2020; Yao et al., 2021; Kiran et al., 2022; Opazo-Rios et al., 2022; Smith et al., 2022). Here, STAT3 is linked to obesity due to melanocortin 4 receptor deficiency.