Studies investigating the prognostic performance of NfL in the context of FTD described a 5-year survival estimate respectively at 36% in FTD patients with a high NfL concentration in the CSF (>3,675 pg/ml) and at 73% in patients whose NfL level was lower than 1,989 pg/ml (both measures determined by ELISA; Meeter et al., 2018). The gene discussed is NEFL; the disease is frontotemporal dementia.