NEFL and neurodegenerative disease: Of note, CSF NfL, either alone or in combination with other biomarkers, yielded a performance similar to t-tau in the distinction of prion disease from other neurodegenerative diseases (AUC 0.926 vs. 0.939) and showed even a higher diagnostic value than t-tau in the specific comparisons between atypical prion disease and other rapidly progressive neurodegenerative dementias (AUC 0.839 vs. 0.722; Abu-Rumeileh and Parchi, 2021).