Sirtuin 1 (SIRT1) is a potent therapeutic strategy against neurodegenerative diseases by downregulating Rho-associated coiled-coil-containing protein kinase 1 (ROCK) expression, and promoting anti-amyloidogenic cleavage of Aβ protein precursors by α-secretase is shown to be thereby inhibiting the aggregation of toxic proteins (Mishra et al., 2021). The gene discussed is SIRT1; the disease is neurodegenerative disease.