The interaction effect of disease status (NC, MCI, and AD) and PHS status (high and low PHS) on the right fimbria-to-hippocampus volume ratio (R. fimbria/hippocampus VR) was statistically significant (Supplementary Table 6: p = 0.020, general linear mixed model controlling age, gender, education, and APOE: ΔF = 4.742, p < 0.001, ΔR2 = 0.172). The gene discussed is APOE; the disease is Pallister-Hall syndrome.