In addition, exercise induces an increase in neurotrophins in AD patients, including the myokine Cathepsin B and BDNF that is closely associated with the status of APOE ε4 in exercisers (Pang et al., 2006; van Dellen et al., 2008; Zajac et al., 2010). The gene discussed is APOE; the disease is Alzheimer disease.