The proteomics analysis showed that exercise downregulated tropomyosin-1 isoforms 33/34, tropomyosin-2, acyl-coenzyme A dehydrogenase, isocitrate dehydrogenase, enolase, probable isocitrate dehydrogenase [NAD] subunit alpha, glycerol-3-phosphate dehydrogenase [NAD (+)], pyruvate dehydrogenase E1 component subunit beta, aldo-keto reductase isoform C, alcohol dehydrogenase, and CG9992 isoform A in PD drosophila. This evidence concerns the gene AKR1A1 and Parkinson disease.