Exercise can reverse many of the PD-related changes by downregulating the levels of hippocampal proteins functionally associated with energy metabolism (nucleoside diphosphate kinase B, enolase, and triosephosphate isomerase) and synaptic plasticity (α-synuclein, tenascin-R, Ba1-667, brevican and neurocan core protein) in the non-lesioned hemisphere of PD model rats (Dimatelis et al., 2013). The gene discussed is SNCA; the disease is Parkinson disease.