APOE and Alzheimer disease: Altered lipid metabolism has been implicated in the pathogenesis of diseases whose risks are modified by APOE ε2/ε3/ε4 polymorphism, such as AD (Zhu et al., 2019; Castor et al., 2020; Yin, 2022) and CAD (Freeman, 2006; Park et al., 2015; Cohain et al., 2021).