Numerous polymorphisms in RYR1 and CACNA1S, which encode the ryanodine receptor and calcium channel in skeletal muscles, respectively, on chromosomes 19 and 1 (56), are associated with malignant hyperthermia when patients are preoperatively exposed to one of the anesthetic agents from the flurane group (desflurane, enflurane, isoflurane, methoxyflurane, sevoflurane), halothane, or succinylcholine (57, 58). The gene discussed is CACNA1S; the disease is Malignant hyperthermia.