SEMA3C protein is a member of the Class 3 semaphorin proteins family, which can interact with neuropilin isoforms (NRP1 and NRP2) and plexin receptors (PLXNA2 and PLXND1) (33, 34), and plays an important role in several respects, such as the neurogenesis (35), cardiac development (36), and promote or inhibit tumor progression (37). This evidence concerns the gene NRP2 and neoplasm.