From 1987, and during the next 23 years, the only ACR criteria biomarker was RF, whereas in the last ACR/EULAR 2010 criteria for the early diagnosis of RA three serological tests were added (ACPA, ESR and CRP) (11) and this demonstrated to improve significantly the clinical management of the disease. The gene discussed is PRTN3; the disease is rheumatoid arthritis.