IFNG and peeling skin syndrome: IFN-γ-producing Th1 cells play a central role in the pathogenesis of the disease, from the onset to its chronic stage, in addition to various immune cells, such as B cells, macrophages, dendritic cells, and NK cells, in the SGs and lacrimal glands of mouse models of pSS and patients with pSS (18, 37–39).