Haplotype CCGGT (consisting of rs11078701C, rs1017163C, rs9898876G, rs62059836G, and rs2541012T) and haplotype CGGT (consisting of rs858521C, rs858518G, rs6259G, and rs727428T) in SHBG and neighboring genes have been associated with a significant risk effect for osteoporosis in Chinese men (41). This evidence concerns the gene SHBG and osteoporosis.