Further filtering the remaining 89 signals based on the validation MR evidence, 7 of them showed MR and LD check evidence in the European validation analysis, including effect of F11 level on VTE, KLKB1 level on VTE, ERAP1 level on POAG, tumor necrosis factor superfamily member 12 (TNFSF12) level on asthma, extracellular matrix protein 1 (ECM1) level on IPF, CD109 level on VTE, and IL-7R level on asthma (Table S16C). The gene discussed is ERAP1; the disease is open-angle glaucoma.