By triangulating these 16 putative causal MR signals with clinical trials and observational evidence, we validated the efficacy of ACE inhibition on COPD and generalized its effect to those of African ancestry, suggested seven drug-repurposing opportunities, and identified seven novel protein-disease pairs that warrant further investigation, for example, the effects of SERPINE2 on VTE. This evidence concerns the gene SERPINE2 and chronic obstructive pulmonary disease.