ACE and chronic obstructive pulmonary disease: As shown in Figure 6A, eight protein-disease pairs were ranked as the most valuable findings after the filtering, which include IL-7R and TNFSF12 level on asthma; ACE level on COPD; AIF1 level on HF; SERPINF1 level on stroke; and SERPINE2, F11, KLKB1, and ABO level on VTE (Figure 6B; Table S18).