Along these lines, Kunert and colleagues reported that the frequency of peripheral CD8 T cells devoid of multiple costimulatory receptors was highest in PR patients with NSCLC at baseline and throughout anti-PD-1 therapy and correlated with the total number of CD8 T cells as well as frequencies of CD8 TEMRA phenotype (50). This evidence concerns the gene CD8A and non-small cell lung carcinoma.