According to guidelines CHB can be classified into four phases: immune tolerance (IT), immune clearance (IC), hepatitis B e antigen (HBeAg)-negative inactive/quiescent carrier (ENQ), and HBeAg-negative hepatitis (ENH) was based on (hepatitis B surface antigen [HBsAg] and HBeAg), HBV DNA, biochemical tests (alanine transaminase [ALT], and liver biopsy) (3–5). This evidence concerns the gene GPT and Hepatitis.