MAPT and amyotrophic lateral sclerosis: In addition, The serum p-tau level in ALS (51.61 ± 2.32 pg/mL) was lower than that in the OND (57.44± 3.42 pg/mL, P = 0.0343), differences were not found in serum p-tau levels between patients with ALS (51.61 ± 2.32 pg/mL) and AM (53.57 ± 3.22 pg/mL, P = 0.8123), data shown in Figure 1D.