MAPT and amyotrophic lateral sclerosis: The CSF p-tau levels in patients with ALS (4.19 ± 0.32 pg/mL) were significantly lower compared with those with OND (23.64 ± 1.49 pg/mL, P < 0.0001), the CSF p-tau levels in patients with OND (23.64 ± 1.49 pg/mL) were significantly higher than AM (5.93 ± 0.77 pg/mL, P < 0.0001).