MAPT and Cognitive impairment: Further analysis indicated that CSF p-tau level was negatively correlated with ECAS total score (r = −0.5502; P = 0.0009), and ALS-specific score (r = −0.5412; P = 0.0011), especially in excutive function (r = −0.4583; P = 0.0073) and verbal fluency in patients with cognitive impairment (r = −0.5525; P = 0.0009).