However, tau can be phosphorylated at several sites, specific residues of tau phosphorylation in ALS in the brain and spinal cord had been found, such as hyperphosphorylated tau (T175, T217, S208/210, S212, S396, and S404), which were increased significantly in the post-mortem motor cortex and spinal cord of ALS. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.