Compared to normal tissue, for approximately all tumor types in TCGA database, ITGAV mRNA expression was significantly overexpressed in invasive breast carcinoma (BRCA), colonic adenocarcinoma (COAD), cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), GBM, head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), pheochromocytoma, paraganglioma (PCPG), rectal adenocarcinoma (READ), gastric adenocarcinoma (STAD), thymic carcinoma, and prostate carcinoma (PRAD; Figure 1E). This evidence concerns the gene ITGAV and paraganglioma.