This would require stratification of sufficient numbers of participants e.g., by age, duration and severity of diabetes/neuropathy, concomitant treatments, etc. We have reported here that the density of regenerating nerve fibers at baseline, marked by GAP43, were related to increased nerve regeneration following Capsaicin 8% patch treatment; this marker may thus identify “responders” for nerve regeneration. Here, GAP43 is linked to neuropathy.