Therefore, this experiment started with Bcl-2/Bax, combined with the data indicators related to the hypothalamic-pituitary-gonadal axis function of endocrine hormones, follicle forming hormone (FSH), luteinizing hormone (LH), etc., to study the mechanism of acupuncture intervention on premature ovarian failure, so as to provide traditional acupuncture technology for treatment. This evidence concerns the gene BCL2 and primary ovarian failure.